Exploring fatty alcohol-producing capability of Yarrowia lipolytica

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Exploring fatty alcohol-producing capability of Yarrowia lipolytica

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Engineering of a high lipid producing Yarrowia lipolytica strain.

BACKGROUND Microbial lipids are produced by many oleaginous organisms including the well-characterized yeast Yarrowia lipolytica, which can be engineered for increased lipid yield by up-regulation of the lipid biosynthetic pathway and down-regulation or deletion of competing pathways. RESULTS We describe a strain engineering strategy centered on diacylglycerol acyltransferase (DGA) gene overe...

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Unraveling fatty acid transport and activation mechanisms in Yarrowia lipolytica.

Fatty acid (FA) transport and activation have been extensively studied in the model yeast species Saccharomyces cerevisiae but have rarely been examined in oleaginous yeasts, such as Yarrowia lipolytica. Because the latter begins to be used in biodiesel production, understanding its FA transport and activation mechanisms is essential. We found that Y. lipolytica has FA transport and activation ...

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ژورنال

عنوان ژورنال: Biotechnology for Biofuels

سال: 2016

ISSN: 1754-6834

DOI: 10.1186/s13068-016-0512-3